Publications

Dale's Principle has historically guided neuroscience research as a valuable rule of thumb, namely that all synapses on each neuron release the same set of neurotransmitters. Most existing Spiking Neuron Network models share this dichotomous assumption that neurons are either excitatory or inhibitory; however, recent experimental evidence points towards co-release mechanisms that violate this assumption. Here, we introduce a minimal model of "Bilingual" neurons violating Dale's principle that can exert both excitatory and inhibitory effects. We identify parameter regimes in which this architecture exhibits transitions between synchronous and asynchronous dynamics that differ quantitatively from those observed in a matched monolingual control architecture. We report distinct information-processing signatures both at the level of neurons and higher-order interactions between them near the phase transitions. These results suggest that the population of neurons violating Dales principle may provide an alternative mechanism for regulating large-scale oscillatory activity in neural circuits.

Collective neural phenomena, such as oscillations and avalanches, are high-level neural signatures observed in aggregated spiking neuronal activity which have been consistently associated with a range of cognitive functions. However, it is often hard to elucidate whether such phenomena are mere epiphenomena or have causal or informational relevance. In this work, we investigate this question by leveraging recent information-theoretic tools to identify emergent phenomena between relevant scales of neural activity. For this, we propose a computational framework combining information-theoretic and network science principles, which we use to investigate emergence in both in-vivo datasets and in-silico simulations. Our approach enables characterisation of emergence phenomena, identifies the relevant scales at which they take place, and elucidates the network-level mechanisms that underpin them. Results show that in-vivo neuronal oscillations show substantial emergent behaviour for smaller prediction delays, while avalanches maintain their emergent nature for larger timescales. These results are supported by in-silico simulations, which show that the emergent signature of oscillations is facilitated by the network structure and interneuronal time-delays. Overall, these results highlight the role of network-level interactions between groups of neuronal assemblies as the key driver of emergent population activity in the brain.

Long-range correlations are a key signature of systems operating near criticality, indicating spatially-extended interactions across large distances. These extended dependencies underlie other emergent properties of critical dynamics, such as high susceptibility and multi-scale coordination. In the brain, along with other signatures of criticality, long-range correlations have been observed across various spatial scales, suggesting that the brain may operate near a critical point to optimize information processing and adaptability. However, the mechanisms underlying these long-range correlations remain poorly understood. Here, we investigate the role of synergistic interactions in mediating long-range correlations in the visual cortex of awake mice. We leverage recent advances in mesoscale two-photon calcium imaging to analyse the activity of thousands of neurons across a wide field of view, allowing us to confirm the presence of long-range correlations at the level of neuronal populations. By applying the Partial Information Decomposition (PID) framework, we decompose the correlations into synergistic and redundant information interactions. Our results reveal that the increase in long-range correlations during visual stimulation is accompanied by a significant increase in synergistic rather than redundant interactions among neurons. Furthermore, we analyse a combined network formed by the union of synergistic and redundant interaction networks, and find that both types of interactions complement each other to facilitate efficient information processing across long distances. This complementarity is further enhanced during the visual stimulation. These findings provide new insights into the computational mechanisms that give rise to long-range correlations in neural systems and highlight the importance of considering different types of information interactions in understanding correlations in the brain.

A central challenge in the study of complex systems is the quantification of emergence -- understood as the ability of the system to exhibit collective behaviours that cannot be traced down to the individual components. While recent work has proposed practical measures to detect emergence, these approaches tend to double-count the contribution of shared components, which substantially hinders their capability to effectively study large systems. In this work, we introduce a family of improved information-theoretic measures of emergence that iteratively correct for double-counted terms. Our approach is computationally efficient and provides a controllable trade-off between computational load and sensitivity, leading to more accurate and versatile estimates of emergence. The benefits of the proposed approach are demonstrated by successfully detecting emergence in both simulated and real-world data related to flocking behaviour.

At what level does natural selection occur? When considering the reproductive dynamics of interacting and mutating agents, it has long been debated whether selection is better understood by focusing on the individual or if hierarchical selection emerges as a consequence of joint adaptation. Despite longstanding efforts in theoretical ecology, there is still no consensus on this fundamental issue, most likely due to the difficulty in obtaining adequate data spanning a sufficient number of generations and the lack of adequate tools to quantify the effect of hierarchical selection. Here, we capitalise on recent advances in information-theoretic data analysis to advance this state of affairs by investigating the emergence of high-order structures- such as groups of species- in the collective dynamics of the Tangled Nature model of evolutionary ecology. Our results show that evolutionary dynamics can lead to clusters of species that act as a self-perpetuating group that exhibits greater information-theoretic agency than a single species for a broad range of stable mutation rates. However, this higher-order organization breaks down for mutation rates close to the error threshold, where increased information processing is observed at the level of a single species. For mutation rates higher than the error threshold, no stable population of species are observed in time, and all individuality is lost in the ecosystem. Overall, our findings provide quantitative evidence supporting the emergence of higher-order structures in evolutionary ecology from relatively simple processes of adaptation and reproduction.

It is a well-known fact that economic growth goes hand in hand with improvements in technological sophistication. While critical to such sophistication, the nature and underlying structure of the input interactions taking place inside production processes remain opaque, at least in the study of large systems such as industries and entire economies. We develop a method to quantify the degree of input complementarity in production processes form input–output data. We propose that the information-theoretic concept of synergistic information is analog to economic complementarity and exploit this link to create a data-driven approach that does not require the ex ante assumption of production functions. In contrast to alternative empirical approaches, our method is able identify input–input interactions and to quantify their contribution to output, revealing an input–input synergistic interaction network that characterizes an industry’s productive technology. We find that more sophisticated industries tend to exhibit highly modular small-world topologies; with the tertiary sector as its central connective core. Overall, countries and industries that have a well-established connective core and specialized modules exhibit higher economic complexity, higher output, and lower emissions. The proposed method provides a framework to identify key relationships in the economy that can enhance economic performance.

Experiences of collective creative activities play an essential role in human societies, yet these experiences are particularly hard to capture, making their scientific study challenging. In a classical music concert-experiment performed by a string quartet, we contrast a Let-go performance mode, characterised by a more creative and improvisatory approach that encourages risk-taking and spontaneous expression, with a more Strict mode which requires adhering closely to the score, common in many Western classical music performance environments. We investigate the experience of audience members by analysing their subjective reports and movement patterns. Our results show that during performances in Let-go mode, movement synchronization was reduced between performers and audience members in shorter timescales, while the synchronization and its temporal variability were enhanced in longer timescales. Furthermore, these differences in the synchronization dynamics are predictive of changes in the audience’s perception of music. These results provide a first step towards the quantification of some of the fundamental aspects of collective music experiences. Specifically, the reported findings demonstrate the relevance of the often-neglected multiscale coordination between audiences and performers, and explain how this rich tapestry of physical behaviour is connected with the quality of the collective music experience.

With the rise of social media, political conversations now take place in more diffuse environments. In this context, it is not always clear why some actors, more than others, have greater influence on how discussions are shaped. To investigate the factors behind such influence, we build on nodality, a concept in political science which describes the capacity of an actor to exchange information within discourse networks. This concept goes beyond traditional network metrics that describe the position of an actor in the network to include exogenous drivers of influence (e.g. factors relating to organisational hierarchies). We study online discourse on Twitter (now X) in the UK to measure the relative nodality of two sets of policy actors - Members of Parliament (MPs) and accredited journalists - on four policy topics. We find that influence on the platform is driven by two key factors: (i) active nodality, derived from the actor's level of topic-related engagement, and (ii) inherent nodality, which is independent of the platform discourse and reflects the actor's institutional position. These findings significantly further our understanding of the origins of influence on social media platforms and suggest in which contexts influence is transferable across topics.

Schizophrenia and states induced by certain psychotomimetic drugs may share some physiological and phenomenological properties, but they differ in fundamental ways: one is a crippling chronic mental disease, while the others are temporary, pharmacologically-induced states presently being explored as treatments for mental illnesses. Building towards a deeper understanding of these different alterations of normal consciousness, here we compare the changes in neural dynamics induced by LSD and ketamine (in healthy volunteers) against those associated with schizophrenia, as observed in resting-state M/EEG recordings. While both conditions exhibit increased neural signal diversity, our findings reveal that this is accompanied by an increased transfer entropy from the front to the back of the brain in schizophrenia, versus an overall reduction under the two drugs. Furthermore, we show that these effects can be reproduced via different alterations of standard Bayesian inference applied on a computational model based on the predictive processing framework. In particular, the effects observed under the drugs are modelled as a reduction of the precision of the priors, while the effects of schizophrenia correspond to an increased precision of sensory information. These findings shed new light on the similarities and differences between schizophrenia and two psychotomimetic drug states, and have potential implications for the study of consciousness and future mental health treatments.

Automated ECG classification is a standard feature in many commercial 12-Lead ECG machines. As part of the Physionet/CinC Challenge 2020, our team, “Mad-hardmax”, developed an XGBoost based classification method for the analysis of 12-Lead ECGs acquired from four different countries. Our aim is to develop an interpretable classifier that outputs diagnoses which can be traced to specific ECG features, while also testing the potential of information theoretic features for ECG diagnosis. These measures capture high-level interdependencies across ECG leads which are effective for discriminating conditions with multiple complex morphologies. On unseen test data, our algorithm achieved a challenge score of 0.155 relative to a winning score of 0.533, putting our submission in 24th position from 41 successful entries.

We study the joint evolution of worldviews by proposing a model of opinion dynamics, which is inspired in notions from evolutionary ecology. Agents update their opinion on a specific issue based on their propensity to change—asserted by the social neighbors—weighted by their mutual similarity on other issues. Agents are, therefore, more influenced by neighbors with similar worldviews (set of opinions on various issues), resulting in a complex co-evolution of each opinion. Simulations show that the worldview evolution exhibits events of intermittent polarization when the social network is scale-free. This, in turn, triggers extreme crashes and surges in the popularity of various opinions. Using the proposed model, we highlight the role of network structure, bounded rationality of agents, and the role of key influential agents in causing polarization and intermittent reformation of worldviews on scale-free networks.

This study takes an interdisciplinary multi-method approach to discovering the contrasting nature and effects of prepared and improvised approaches during live chamber-music concert performances of a movement from Franz Schubert's “Shepherd on the Rock,” given by a professional trio consisting of voice, flute, and piano, in the presence of an invited audience of 22 adults with varying levels of musical experience and training. EEG measurements from 19 scalp locations showed higher levels of Lempel-Ziv complexity (associated with awareness and alertness) in the improvised version in both performers and audience. Results are discussed in terms of their potential support for an “improvisatory state of mind” which may have aspects of flow (as characterized by Csikszentmihalyi, 1997) and primary states (as characterized by the Entropic Brain Hypothesis of Carhart-Harris et al., 2014)

We discuss the strategy that rational agents can use to maximize their expected long-term payoff in the co-action minority game. We argue that the agents will try to get into a cyclic state, where each of the (2𝑁+1) agents wins exactly N times in any continuous stretch of (2𝑁+1) days. We propose and analyse a strategy for reaching such a cyclic state quickly, when any direct communication between agents is not allowed, and only the publicly available common information is the record of total number of people choosing the first restaurant in the past. We determine exactly the average time required to reach the periodic state for this strategy.